Архив номеров журнала "Кардиология"

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Журнал "Кардиология" №4, 2007

Особенности распределения полиморфных маркеров генов ренин-ангиотензин-альдостероновой системы, связь с гипертрофией левого желудочка у больных эссенциальной гипертонией узбекской национальности

Peculiarities of Distribution of Polymorphic Markers of Renin Angiotensin System Genes, Relation to Ventricular Hypertrophy in Patients With Essential Hypertension of Uzbek Nationality

Aim. To study distribution of polymorphisms of angiotensin converting enzyme (ACE), angiotensin II type 1 receptor (AT1R), aldosterone synthase (CYP11B2) genes, and their association with processes of left ventricular remodeling in men of uzbek nationality with essential hypertension (EH). Material and methods. Patients with stage 1–2 EH were genotyped for carrying I/D polymorphism of ACE gene, A1166C polymorphism of AT1R gene, and C(–344)T polymorphism of CYP11B2 gene. Echocardiography was used for measurement of left ventricular myocardial mass index. Results and conclusions. Special features of distribution of studied genes among uzbek men were the following: accumulation of ID-genotype of I/D polymorphic marker of ACE gene among patients with EH, predominance of I-allele and II-genotype of ACE gene in healthy persons; accumulation of AA-genotype and A-allele of A1166C polymorphic marker of AT1R gene in patients with EH and healthy persons, while CC genotype was found only in patients with EH; predominance of CT genotype of C(–344)T polymorphic marker of CYP11B2 gene in patients with EH and healthy persons with high prevalence of T-allele in patients with EH. Carriage of TT genotype of C(-344)T polymorphic marker of CYP11B2 was associated with higher values of diastolic blood pressure. Associations were revealed between carriage of TT-genotype and T-allele of CYP11B2 gene, AC+CC-genotypes of AR1R gene and severity of left ventricular hypertrophy.

Keywords: essential hypertension; gene polymorphism of renin angiotensin aldosterone system; left ventricular hypertrophy.

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